Mathematical model of psoriasis incorporating cytokines dynamics
2016
University of Kent, Canterbury, United Kingdom
Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. As far as now, the computational model of psoriasis have lacked integration of the dynamics of cytokines, the signalling molecules of the immune system. In the present study, the researchers develop a mathematical model of psoriasis is developed incorporating interactions between different cell types, mediated by the cytokines they produce. The possibility of some of the cytokines acting as fast actuators to the cell population dynamics was investigated. The analysis shows that the system can display two steady states reflecting normal and psoriatic skin conditions. The study explores the inherent finite time nature of the underlying biology of psoriasis and demonstrates an analysis approach that could be used for other biological systems.
Modelling and finite-time stability analysis of psoriasis pathogenesis
Sarah K. Spurgeon
Added on: 10-28-2021
[1] https://www.tandfonline.com/doi/abs/10.1080/00207179.2016.1217566?journalCode=tcon20[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
