In silico model of cerebrospinal venous circulation
2015
IRCCS Santa Maria Nascente, Milano, Italy
In recent years, the relationship between extracranial venous system abnormalities and central nervous system (CNS) pathologies has been scrutinized but no clear link has ever been demonstrated. In the present study, the researchers aimed at shedding light on the matter by creating an in silico model of cerebrospinal venous drainage from anatomical data taken from the literature. Effects of the obstruction of the main venous outflows were simulated and the model was used to reanalyze the 112 Multiple Sclerosis patients. The model developed in the study can predict physiological and pathological behaviours with good fidelity. Further development of the model should take into account different body positions.
An anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamics?
Maria Marcella Laganà
Added on: 11-28-2021
[1] https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-015-0352-y[2] https://data.jrc.ec.europa.eu/dataset/20947a04-86ef-473f-8907-c658e4050c24
