In silico models of heart electrophysiology in ischemic conditions
2017
University of Oxford, Oxford, United Kingdom
One of the major causes of sudden cardiac death is acute myocardial ischemia, resulting from an imbalance in the supply and demand of oxygen and nutrients to the heart. During the first 10–15 min of ischemia, metabolic and electrophysiological changes occur rapidly and vary spatially. In the present study, the researchers aimed at investigating the response of four recent computational human-specific ventricular action potential (AP) models to varied ischemic conditions by comparing electrophysiological properties in single-cell and tissue simulations to assess their utility for studying mechanisms of arrhythmogenesis during the initial phase of acute myocardial ischemia. The study concludes that quantitative differences are observed between the models and overall, the ten Tusscher and modified O'Hara models show the closest agreement to experimental data.
Electrophysiological properties of computational human ventricular cell action potential models under acute ischemic conditions
Sara Dutta
Added on: 12-01-2021
[1] https://www.sciencedirect.com/science/article/pii/S0079610716300918?via%3Dihub[2] https://data.jrc.ec.europa.eu/dataset/20947a04-86ef-473f-8907-c658e4050c24
