Loss of coordination between basic cellular processes in human aging
2024
University of Cologne, Cologne, Germany
This study presents a method to quantify age-related changes in the regulatory relationships between genes. The method analyses gene-gene relationships across the transcriptome using RNA sequencing data from 948 human donors aged between 20 and 79 years from the Genotype-Tissue Expression (GTEx) project. Analysis of eight different human tissues revealed that these gene-gene relationships can both strengthen and weaken with age, impacting both tissue-specific and general biological functions. The findings suggest that ageing does not lead to a global deregulation of gene expression, but rather that most changes in gene-gene relationships are due to a loss of coordination between different cellular processes.
Loss of coordination between basic cellular processes in human aging
Andreas Beyer
Added on: 02-05-2025
[1] https://www.nature.com/articles/s43587-024-00696-y
