NAM-based toolbox for human inhalation toxicity
2025
Unilever, Sharnbrook, United Kingdom
In this study, 3D models of human lung cells (MucilAir™-HF for the upper and EpiAlveolar™ for the lower airways) as well as computational models for calculating lung exposure were used. Eleven chemicals were tested over a period of 12 days, including safe substances such as coumarin and known harmful substances such as crystalline silica. Cell damage, inflammatory reactions, and genetic changes were analysed. The results show that the safe chemicals did not cause harmful effects, while toxic substances triggered strong inflammatory reactions and lung damage. The combination of in vitro and computational models was able to distinguish between harmless and hazardous substances in most cases.
Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety
Maria Baltazar
Added on: 02-24-2025
[1] https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2025.1426132/full
