New organ-on-a-chip system to study the intestine
2020
Utrecht University, Utrecht, Netherlands
In this study, a new intestinal organ-on-a-chip model was developed. The fluid flow was calculated to accurately mimic the shear stress. The results show improved differentiation of the employed CaCo2-cells (a cell line of human colorectal adenocarcinoma) to intestinal epithelial cells (tighter monolayer formation, higher p-cresol metabolic capacity, improved brush border activity and villi formation).
A theoretical and experimental study to optimize cell differentiation in a novel intestinal chip
Rosalinde Masereeuw
Added on: 11-20-2020
[1] https://www.frontiersin.org/articles/10.3389/fbioe.2020.00763/full[2] https://www.uu.nl/en/news/new-miniature-system-to-study-kidney-and-intestine-function
