Single-cell test of cancer drugs
2021
University of Chinese Academy of Sciences, Beijing, China
The researchers paired a powerful algorithm with Raman spectroscopy, which involves using a laser to excite photons in a sample to reveal structural information, including interactions. They examined how rapamycin, an anti-cancer drug, changed the metabolic activity in a human cancer cell line and in yeast. The method is able to rapidly and precisely track and distinguish changes in lipid and protein metabolic-inhibitory effect of rapamycin. The method takes just days compared to traditional tests that can take much longer to see if an individual patient's cells will respond favourably to a drug. It is also very precise, as it can distinguish cancer cell responses to drugs at the single-cell and single-organelle resolution, which is crucial for understanding why the drug is - or is not – effective.
D2O-probed Raman microspectroscopy distinguishes the metabolic dynamics of macromolecules in organellar anticancer drug response
Jian Xu, Maryam Hekmatara
Added on: 01-29-2021
[1] https://pubs.acs.org/doi/10.1021/acs.analchem.0c03925[2] https://www.bionity.com/en/news/1169538/single-cell-test-can-reveal-precisely-how-drugs-kill-cancer-cells.html
