Mathematical model for reactive oxygen species-induced cell death mechanisms
2016
University of Waterloo, Waterloo, Canada
A mathematical model is used to understand and decipher the mechanisms of ascorbic acid-induced cytotoxicity on cancer cells. This model determines that reactive oxygen species-induced cell death relies on membrane properties. This is confirmed with experimental data from in vitro assays with human breast cancer cells. These findings provide key insights in the mechanisms of ascorbic acid-induced cancer cell death and confirm this model as a potential tool to understand the mechanisms of selective drugs.
Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects
Mohammad Kohandel, Hamid R Molavian
Added on: 07-21-2021
[1] https://www.nature.com/articles/srep27439[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
