Mathematical modelling to improve immunotherapy design for colorectal cancer
2017
University Hospital Heidelberg, Heidelberg, Germany
To improve immunotherapy results in colorectal cancer patients, a better understanding of the complex immunological interplay within the microenvironment is crucial. In this study, the researchers generated a mathematical model from quantitative histological data from cancer patients. This model incorporates stochastic interactions between tumor cells, immune cells, and stroma and faithfully represents diverse spatial patterns observed in histological samples of human colorectal cancer tissue. This model was then used to systematically test the effect of different therapeutic interventions on this system and to create specific recommendations for effective
immunotherapies.
In silico modeling of immunotherapy and stroma- targeting therapies in human colorectal cancer
Niels Halama
Added on: 07-26-2021
[1] https://cancerres.aacrjournals.org/content/77/22/6442[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
