Mathematical model of cancer antigen binding
October 2014
National Institutes of Health, Bethesda, USA(1)
Pusan National University, Busan, South Korea(2)
Pusan National University, Busan, South Korea(2)
Immunotoxins and antibody-drug conjugates are designed to bind to specific target antigens on tumor cells and kill these cells. Most cancer-specific antigens are shed from the cell surface without clear knowledge on how this process can affect the delivery efficiency of antibody-drug conjugates and immunotoxins.
In this study, the researchers used a mathematical model to reproduce the kinetic events happening in the blood flow, extracellular space and tumors. The model shows that shedding can reduce, as well as enhance, antitumor activity depending on the number of antigen molecules on the cell surface. It raises the possibility of a new mechanism by which receptor shedding can regulate signaling in normal tissues.
Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model
Byungkook Lee(1), Youngshang Pak(2)
Added on: 07-27-2021
[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110716[2] https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573
