Computational approach to model estrogen regulation of amyloid beta production
2013
University of Illinois at Urbana-Champaign, Urbana, USA
Amyloid-beta accumulation in Alzheimer's disease is a complex process that is not well understood. Despite this, estrogen is known to influence the regulation of its production. Here, a computational approach is used to model the complex contribution of estrogen to amyloid-beta regulation. The results show that by using estrogen it is possible to induce the reduction of amyloid-beta levels. The model also shows the mechanisms behind this potential reduction and that the use of non-steroidal anti-inflammatory drugs could be used as an additional treatment. It also describes a series of other compounds that could be also used synergistically with estrogen to further decrease the amyloid-beta levels. The results show that this model could be used as a starting point for drug development and to understand the mechanisms behind them.
Exploring the contribution of estrogen to amyloid-beta regulation: a novel multifactorial computational modeling approach
Thomas J Anastasio
Added on: 08-08-2021
[1] https://www.frontiersin.org/articles/10.3389/fphar.2013.00016/full[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
