Computational model of the basal ganglia
2017
University of Sheffield, Sheffield, United Kingdom
Neural oscillations in the basal ganglia are well-studied and have been described to correlate with behaviour. However, the mechanisms underlying this correlation and their functional significance are not well understood. Here, a computational model of the basal ganglia is developed and fitted to experimental recordings of nuclei of the basal ganglia after cortical stimulation and used to predict the causal mechanisms of different frequency bands. This new model allowed the researchers to observe that inputs related to motor tasks induced beta and gamma frequency oscillations as seen in vivo and identified which network pathways are required to observe these frequencies. The evidence in this study suggests that this new model can provide a coherent framework to analyse several features of the healthy basal ganglia and sets the basis for a better comprehension of basal ganglia-related pathologies like Parkinson's disease.
Frequency and function in the basal ganglia: the origins of beta and gamma band activity
Alexander Blenkinsop
Added on: 09-30-2021
[1] https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP273760[2] https://data.jrc.ec.europa.eu/dataset/a8fd26ef-b113-47ab-92ba-fd2be449c7eb
